publications

• Lack of utility of SDHB mutation testing in adrenergic metastatic phaeochromocytoma.

  European journal of endocrinology. 2015 Feb;172(2):89-95

  Authors: Sue M, Martucci V, Frey F, Lenders JM, Timmers HJ, Peczkowska M, Prejbisz A, Swantje B, Bornstein SR, Arlt W, Fassnacht M, Beuschlein F, Robledo M, Pacak K, Eisenhofer G

  

• 2D-DIGE proteomic analysis identifies new potential therapeutic targets for adrenocortical carcinoma.

  Oncotarget. 2015 Mar 20;6(8):5695-706

  Authors: Poli G, Ceni E, Armignacco R, Ercolino T, Canu L, Baroni G, Nesi G, Galli A, Mannelli M, Luconi M

     

• Toward an improved definition of the genetic and tumor spectrum associated with SDH germ-line mutations.

  Genetics in medicine : official journal of the American College of Medical Genetics. 2015 Aug;17(8):610-20

  Authors: Evenepoel L, Papathomas TG, Krol N, Korpershoek E, de Krijger RR, Persu A, Dinjens WN

  

• SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: a multicenter interobserver variation analysis using virtual microscopy: a Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T).

  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2015 Jun;28(6):807-21

  Authors: Papathomas TG, Oudijk L, Persu A, Gill AJ, van Nederveen F, Tischler AS, Tissier F, Volante M, Matias-Guiu X, Smid M, Favier J, Rapizzi E, Libe R, Currás-Freixes M, Aydin S, Huynh T, Lichtenauer U, van Berkel A, Canu L, Domingues R, Clifton-Bligh RJ, Bialas M, Vikkula M, Baretton G, Papotti M, Nesi G, Badoual C, Pacak K, Eisenhofer G, Timmers HJ, Beuschlein F, Bertherat J, Mannelli M, Robledo M, Gimenez-Roqueplo AP, Dinjens WN, Korpershoek E, de Krijger RR

  

• Immunohistochemical expression of stem cell markers in pheochromocytomas/paragangliomas is associated with SDHx mutations.

  European journal of endocrinology. 2015 Jul;173(1):43-52

  Authors: Oudijk L, Neuhofer CM, Lichtenauer UD, Papathomas TG, Korpershoek E, Stoop H, Oosterhuis JW, Smid M, Restuccia DF, Robledo M, de Cubas AA, Mannelli M, Gimenez-Roqueplo AP, Dinjens WN, Beuschlein F, de Krijger RR

  

• DNA Methylation Profiling in Pheochromocytoma and Paraganglioma Reveals Diagnostic and Prognostic Markers.

  Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 Jul 1;21(13):3020-30

  Authors: de Cubas AA, Korpershoek E, Inglada-Pérez L, Letouzé E, Currás-Freixes M, Fernández AF, Comino-Méndez I, Schiavi F, Mancikova V, Eisenhofer G, Mannelli M, Opocher G, Timmers H, Beuschlein F, de Krijger R, Cascon A, Rodríguez-Antona C, Fraga MF, Favier J, Gimenez-Roqueplo AP, Robledo M

  

• Vascular pattern analysis for the prediction of clinical behaviour in pheochromocytomas and paragangliomas.

  PloS one. 2015;10(3):e0121361

  Authors: Oudijk L, van Nederveen F, Badoual C, Tissier F, Tischler AS, Smid M, Gaal J, Lepoutre-Lussey C, Gimenez-Roqueplo AP, Dinjens WN, Korpershoek E, de Krijger R, Favier J

     

• Major prognostic role of Ki67 in localized adrenocortical carcinoma after complete resection.

  The Journal of clinical endocrinology and metabolism. 2015 Mar;100(3):841-9

  Authors: Beuschlein F, Weigel J, Saeger W, Kroiss M, Wild V, Daffara F, Libé R, Ardito A, Al Ghuzlan A, Quinkler M, Oßwald A, Ronchi CL, de Krijger R, Feelders RA, Waldmann J, Willenberg HS, Deutschbein T, Stell A, Reincke M, Papotti M, Baudin E, Tissier F, Haak HR, Loli P, Terzolo M, Allolio B, Müller HH, Fassnacht M

  

• Interference from 3-O-methyldopa with ultra-high performance LC-MS/MS measurements of plasma metanephrines: chromatographic separation remains important.

  Clinical chemistry. 2015 Jul;61(7):993-6

  Authors: Peitzsch M, Adaway JE, Eisenhofer G

  

• Measurements of plasma metanephrines by immunoassay vs liquid chromatography with tandem mass spectrometry for diagnosis of pheochromocytoma.

  European journal of endocrinology. 2015 Mar;172(3):251-60

  Authors: Weismann D, Peitzsch M, Raida A, Prejbisz A, Gosk M, Riester A, Willenberg HS, Klemm R, Manz G, Deutschbein T, Kroiss M, Därr R, Bidlingmaier M, Januszewicz A, Eisenhofer G, Fassnacht M

  

• Semiquantitative 123I-Metaiodobenzylguanidine Scintigraphy to Distinguish Pheochromocytoma and Paraganglioma from Physiologic Adrenal Uptake and Its Correlation with Genotype-Dependent Expression of Catecholamine Transporters.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2015 Jun;56(6):839-46

  Authors: van Berkel A, Rao JU, Lenders JW, Pellegata NS, Kusters B, Piscaer I, Hermus AR, Plantinga TS, Langenhuijsen JF, Vriens D, Janssen MJ, Gotthardt M, Timmers HJ

  

• Genotype-specific differences in the tumor metabolite profile of pheochromocytoma and paraganglioma using untargeted and targeted metabolomics.

  The Journal of clinical endocrinology and metabolism. 2015 Feb;100(2):E214-22

  Authors: Rao JU, Engelke UF, Sweep FC, Pacak K, Kusters B, Goudswaard AG, Hermus AR, Mensenkamp AR, Eisenhofer G, Qin N, Richter S, Kunst HP, Timmers HJ, Wevers RA

     

• Adrenocortical growth and cancer.

  Comprehensive Physiology. 2015 Jan;5(1):293-326

  Authors: Lefèvre L, Bertherat J, Ragazzon B

  

• From Nf1 to Sdhb knockout: Successes and failures in the quest for animal models of pheochromocytoma.

  Molecular and cellular endocrinology. 2016 Feb 5;421:40-8

  Authors: Lepoutre-Lussey C, Thibault C, Buffet A, Morin A, Badoual C, Bénit P, Rustin P, Ottolenghi C, Janin M, Castro-Vega LJ, Trapman J, Gimenez-Roqueplo AP, Favier J

  

• Deciphering the molecular basis of invasiveness in Sdhb-deficient cells.

  Oncotarget. 2015 Oct 20;6(32):32955-65

  Authors: Loriot C, Domingues M, Berger A, Menara M, Ruel M, Morin A, Castro-Vega LJ, Letouzé É, Martinelli C, Bemelmans AP, Larue L, Gimenez-Roqueplo AP, Favier J

     

• Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas.

  Nature communications. 2015 Jan 27;6:6044

  Authors: Castro-Vega LJ, Letouzé E, Burnichon N, Buffet A, Disderot PH, Khalifa E, Loriot C, Elarouci N, Morin A, Menara M, Lepoutre-Lussey C, Badoual C, Sibony M, Dousset B, Libé R, Zinzindohoue F, Plouin PF, Bertherat J, Amar L, de Reyniès A, Favier J, Gimenez-Roqueplo AP

     

• Rethinking pheochromocytomas and paragangliomas from a genomic perspective.

  Oncogene. 2016 Mar 3;35(9):1080-9

  Authors: Castro-Vega LJ, Lepoutre-Lussey C, Gimenez-Roqueplo AP, Favier J

  

• Paraganglioma and phaeochromocytoma: from genetics to personalized medicine.

  Nature reviews. Endocrinology. 2015 Feb;11(2):101-11

  Authors: Favier J, Amar L, Gimenez-Roqueplo AP

  

• Succinate Dehydrogenase (SDH)-Deficient Pancreatic Neuroendocrine Tumor Expands the SDH-Related Tumor Spectrum.

  The Journal of clinical endocrinology and metabolism. 2015 Oct;100(10):E1386-93

  Authors: Niemeijer ND, Papathomas TG, Korpershoek E, de Krijger RR, Oudijk L, Morreau H, Bayley JP, Hes FJ, Jansen JC, Dinjens WN, Corssmit EP

  

• Pheochromocytoma and paraganglioma: molecular testing and personalized medicine.

  Current opinion in oncology. 2016 Jan;28(1):5-10

  Authors: Burnichon N, Buffet A, Gimenez-Roqueplo AP

  

• Genome-wide paternal uniparental disomy as a cause of Beckwith-Wiedemann syndrome associated with recurrent virilizing adrenocortical tumors.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2015 Jun;47(7):497-503

  Authors: Bertoin F, Letouzé E, Grignani P, Patey M, Rossignol S, Libé R, Pasqual C, Lardière-Deguelte S, Hoeffel-Fornes C, Gaillard D, Previderè C, Delemer B, Lalli E

  

• How genomic studies have improved our understanding of the mechanisms of transcriptional regulation by NR5A nuclear receptors.

  Molecular and cellular endocrinology. 2015 Jun 15;408:138-44

  Authors: Ruggiero C, Doghman M, Lalli E

  

• Role of Endocrine Gland-Derived Vascular Endothelial Growth Factor (EG-VEGF) and Its Receptors in Adrenocortical Tumors.

  Hormones & cancer. 2015 Dec;6(5-6):225-36

  Authors: Heck D, Wortmann S, Kraus L, Ronchi CL, Sinnott RO, Fassnacht M, Sbiera S

     

• Mitogen-Activated Protein Kinase Pathway: Genetic Analysis of 95 Adrenocortical Tumors.

  Cancer investigation. 2015;33(10):526-31

  Authors: Rubin B, Monticelli H, Redaelli M, Mucignat C, Barollo S, Bertazza L, Mian C, Betterle C, Iacobone M, Fassina A, Boscaro M, Pezzani R, Mantero F

  

2014

• Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency.

  The Journal of clinical endocrinology and metabolism. 2014 Oct;99(10):3903-11

  Authors: Richter S, Peitzsch M, Rapizzi E, Lenders JW, Qin N, de Cubas AA, Schiavi F, Rao JU, Beuschlein F, Quinkler M, Timmers HJ, Opocher G, Mannelli M, Pacak K, Robledo M, Eisenhofer G

     

• Liposomal polychemotherapy improves adrenocortical carcinoma treatment in a preclinical rodent model.

  Endocrine-related cancer. 2014 Jun;21(3):383-94

  Authors: Hantel C, Jung S, Mussack T, Reincke M, Beuschlein F

  

• Telomerase reverse transcriptase promoter mutations in tumors originating from the adrenal gland and extra-adrenal paraganglia.

  Endocrine-related cancer. 2014 Aug;21(4):653-61

  Authors: Papathomas TG, Oudijk L, Zwarthoff EC, Post E, Duijkers FA, van Noesel MM, Hofland LJ, Pollard PJ, Maher ER, Restuccia DF, Feelders RA, Franssen GJ, Timmers HJ, Sleijfer S, de Herder WW, de Krijger RR, Dinjens WN, Korpershoek E

  

• H-RAS mutations are restricted to sporadic pheochromocytomas lacking specific clinical or pathological features: data from a multi-institutional series.

  The Journal of clinical endocrinology and metabolism. 2014 Jul;99(7):E1376-80

  Authors: Oudijk L, de Krijger RR, Rapa I, Beuschlein F, de Cubas AA, Dei Tos AP, Dinjens WN, Korpershoek E, Mancikova V, Mannelli M, Papotti M, Vatrano S, Robledo M, Volante M

  

• Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X.

  International journal of cancer. 2014 Nov 1;135(9):2054-64

  Authors: Qin N, de Cubas AA, Garcia-Martin R, Richter S, Peitzsch M, Menschikowski M, Lenders JW, Timmers HJ, Mannelli M, Opocher G, Economopoulou M, Siegert G, Chavakis T, Pacak K, Robledo M, Eisenhofer G

  

• Integrated genomic characterization of adrenocortical carcinoma.

  Nature genetics. 2014 Jun;46(6):607-12

  Authors: Assié G, Letouzé E, Fassnacht M, Jouinot A, Luscap W, Barreau O, Omeiri H, Rodriguez S, Perlemoine K, René-Corail F, Elarouci N, Sbiera S, Kroiss M, Allolio B, Waldmann J, Quinkler M, Mannelli M, Mantero F, Papathomas T, De Krijger R, Tabarin A, Kerlan V, Baudin E, Tissier F, Dousset B, Groussin L, Amar L, Clauser E, Bertagna X, Ragazzon B, Beuschlein F, Libé R, de Reyniès A, Bertherat J

  

• Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas.

  Human molecular genetics. 2014 May 1;23(9):2440-6

  Authors: Castro-Vega LJ, Buffet A, De Cubas AA, Cascón A, Menara M, Khalifa E, Amar L, Azriel S, Bourdeau I, Chabre O, Currás-Freixes M, Franco-Vidal V, Guillaud-Bataille M, Simian C, Morin A, Letón R, Gómez-Graña A, Pollard PJ, Rustin P, Robledo M, Favier J, Gimenez-Roqueplo AP

  

• Pitfalls in genetic analysis of pheochromocytomas/paragangliomas-case report.

  The Journal of clinical endocrinology and metabolism. 2014 Jul;99(7):2321-6

  Authors: Canu L, Rapizzi E, Zampetti B, Fucci R, Nesi G, Richter S, Qin N, Giachè V, Bergamini C, Parenti G, Valeri A, Ercolino T, Eisenhofer G, Mannelli M

  

• Automated Selection of Hotspots (ASH): enhanced automated segmentation and adaptive step finding for Ki67 hotspot detection in adrenal cortical cancer.

  Diagnostic pathology. 2014 Nov 25;9:216

  Authors: Lu H, Papathomas TG, van Zessen D, Palli I, de Krijger RR, van der Spek PJ, Dinjens WN, Stubbs AP

     

• Vanin-1 inactivation antagonizes the development of adrenocortical neoplasia in Sf-1 transgenic mice.

  Endocrinology. 2014 Jul;155(7):2349-54

  Authors: Latre de Late P, El Wakil A, Jarjat M, de Krijger RR, Heckert LL, Naquet P, Lalli E

  

• Correlation between in vivo 18F-FDG PET and immunohistochemical markers of glucose uptake and metabolism in pheochromocytoma and paraganglioma.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2014 Aug;55(8):1253-9

  Authors: van Berkel A, Rao JU, Kusters B, Demir T, Visser E, Mensenkamp AR, van der Laak JA, Oosterwijk E, Lenders JW, Sweep FC, Wevers RA, Hermus AR, Langenhuijsen JF, Kunst DP, Pacak K, Gotthardt M, Timmers HJ

  

• Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.

  The Journal of clinical endocrinology and metabolism. 2014 Oct;99(10):E2093-100

  Authors: Di Dalmazi G, Kisker C, Calebiro D, Mannelli M, Canu L, Arnaldi G, Quinkler M, Rayes N, Tabarin A, Laure Jullié M, Mantero F, Rubin B, Waldmann J, Bartsch DK, Pasquali R, Lohse M, Allolio B, Fassnacht M, Beuschlein F, Reincke M

  

• Laboratory evaluation of pheochromocytoma and paraganglioma.

  Clinical chemistry. 2014 Dec;60(12):1486-99

  Authors: Eisenhofer G, Peitzsch M

  

• Neuroendocrine cancer. Closing the GAPP on predicting metastases.

  Nature reviews. Endocrinology. 2014 Jun;10(6):315-6

  Authors: Eisenhofer G, Tischler AS

  

• Diagnosis of endocrine disease: Biochemical diagnosis of phaeochromocytoma and paraganglioma.

  European journal of endocrinology. 2014 Mar;170(3):R109-19

  Authors: van Berkel A, Lenders JW, Timmers HJ

  

• Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome.

  The New England journal of medicine. 2014 Mar 13;370(11):1019-28

  Authors: Beuschlein F, Fassnacht M, Assié G, Calebiro D, Stratakis CA, Osswald A, Ronchi CL, Wieland T, Sbiera S, Faucz FR, Schaak K, Schmittfull A, Schwarzmayr T, Barreau O, Vezzosi D, Rizk-Rabin M, Zabel U, Szarek E, Salpea P, Forlino A, Vetro A, Zuffardi O, Kisker C, Diener S, Meitinger T, Lohse MJ, Reincke M, Bertherat J, Strom TM, Allolio B

     

• The 'omics' of adrenocortical tumours for personalized medicine.

  Nature reviews. Endocrinology. 2014 Apr;10(4):215-28

  Authors: Assié G, Jouinot A, Bertherat J

  

• Mass-array screening of frequent mutations in cancers reveals RB1 alterations in aggressive adrenocortical carcinomas.

  European journal of endocrinology. 2014 Mar;170(3):385-91

  Authors: Ragazzon B, Libé R, Assié G, Tissier F, Barreau O, Houdayer C, Perlemoine K, Audebourg A, Clauser E, René-Corail F, Bertagna X, Dousset B, Bertherat J, Groussin L

  

• Oncometabolites-driven tumorigenesis: From genetics to targeted therapy.

  International journal of cancer. 2014 Nov 15;135(10):2237-48

  Authors: Morin A, Letouzé E, Gimenez-Roqueplo AP, Favier J

  

• Biochemical diagnosis of phaeochromocytoma using plasma-free normetanephrine, metanephrine and methoxytyramine: importance of supine sampling under fasting conditions.

  Clinical endocrinology. 2014 Apr;80(4):478-86

  Authors: Därr R, Pamporaki C, Peitzsch M, Miehle K, Prejbisz A, Peczkowska M, Weismann D, Beuschlein F, Sinnott R, Bornstein SR, Neumann HP, Januszewicz A, Lenders J, Eisenhofer G

  

• The antiproliferative effects of ouabain and everolimus on adrenocortical tumor cells.

  Endocrine journal. 2014;61(1):41-53

  Authors: Pezzani R, Rubin B, Redaelli M, Radu C, Barollo S, Cicala MV, Salvà M, Mian C, Mucignat-Caretta C, Simioni P, Iacobone M, Mantero F

  

• Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis.

  European journal of endocrinology. 2014 Jan;170(1):1-12

  Authors: Papathomas TG, Gaal J, Corssmit EP, Oudijk L, Korpershoek E, Heimdal K, Bayley JP, Morreau H, van Dooren M, Papaspyrou K, Schreiner T, Hansen T, Andresen PA, Restuccia DF, van Kessel I, van Leenders GJ, Kros JM, Looijenga LH, Hofland LJ, Mann W, van Nederveen FH, Mete O, Asa SL, de Krijger RR, Dinjens WN

  

2013

• Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R.

  PloS one. 2013;8(2):e55743

  Authors: Gaujoux S, Hantel C, Launay P, Bonnet S, Perlemoine K, Lefèvre L, Guillaud-Bataille M, Beuschlein F, Tissier F, Bertherat J, Rizk-Rabin M, Ragazzon B

     

• Integrative analysis of miRNA and mRNA expression profiles in pheochromocytoma and paraganglioma identifies genotype-specific markers and potentially regulated pathways.

  Endocrine-related cancer. 2013 Aug;20(4):477-93

  Authors: de Cubas AA, Leandro-García LJ, Schiavi F, Mancikova V, Comino-Méndez I, Inglada-Pérez L, Perez-Martinez M, Ibarz N, Ximénez-Embún P, López-Jiménez E, Maliszewska A, Letón R, Gómez Graña A, Bernal C, Alvarez-Escolá C, Rodríguez-Antona C, Opocher G, Muñoz J, Megias D, Cascón A, Robledo M

  

• SDHA mutations in adult and pediatric wild-type gastrointestinal stromal tumors.

  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2013 Mar;26(3):456-63

  Authors: Oudijk L, Gaal J, Korpershoek E, van Nederveen FH, Kelly L, Schiavon G, Verweij J, Mathijssen RH, den Bakker MA, Oldenburg RA, van Loon RL, O'Sullivan MJ, de Krijger RR, Dinjens WN

  

• Identification of a CpG island methylator phenotype in adrenocortical carcinomas.

  The Journal of clinical endocrinology and metabolism. 2013 Jan;98(1):E174-84

  Authors: Barreau O, Assié G, Wilmot-Roussel H, Ragazzon B, Baudry C, Perlemoine K, René-Corail F, Bertagna X, Dousset B, Hamzaoui N, Tissier F, de Reynies A, Bertherat J

  

• Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5α-reductase, explaining the need for personalized glucocorticoid and androgen replacement.

  The Journal of clinical endocrinology and metabolism. 2013 Jan;98(1):161-71

  Authors: Chortis V, Taylor AE, Schneider P, Tomlinson JW, Hughes BA, O'Neil DM, Libé R, Allolio B, Bertagna X, Bertherat J, Beuschlein F, Fassnacht M, Karavitaki N, Mannelli M, Mantero F, Opocher G, Porfiri E, Quinkler M, Sherlock M, Terzolo M, Nightingale P, Shackleton CH, Stewart PM, Hahner S, Arlt W

  

• Morphofunctional effects of mitotane on mitochondria in human adrenocortical cancer cells.

  Endocrine-related cancer. 2013 Aug;20(4):537-50

  Authors: Poli G, Guasti D, Rapizzi E, Fucci R, Canu L, Bandini A, Cini N, Bani D, Mannelli M, Luconi M

  

• Simultaneous liquid chromatography tandem mass spectrometric determination of urinary free metanephrines and catecholamines, with comparisons of free and deconjugated metabolites.

  Clinica chimica acta; international journal of clinical chemistry. 2013 Mar 15;418:50-8

  Authors: Peitzsch M, Pelzel D, Glöckner S, Prejbisz A, Fassnacht M, Beuschlein F, Januszewicz A, Siegert G, Eisenhofer G

  

• Detection of circulating tumor cells in patients with adrenocortical carcinoma: a monocentric preliminary study.

  The Journal of clinical endocrinology and metabolism. 2013 Sep;98(9):3731-8

  Authors: Pinzani P, Scatena C, Salvianti F, Corsini E, Canu L, Poli G, Paglierani M, Piccini V, Pazzagli M, Nesi G, Mannelli M, Luconi M

  

• Lack of long-lasting effects of mitotane adjuvant therapy in a mouse xenograft model of adrenocortical carcinoma.

  Molecular and cellular endocrinology. 2013 Dec 5;381(1-2):66-9

  Authors: Doghman M, Lalli E

  

• Genotype-specific abnormalities in mitochondrial function associate with distinct profiles of energy metabolism and catecholamine content in pheochromocytoma and paraganglioma.

  Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 Jul 15;19(14):3787-95

  Authors: Rao JU, Engelke UF, Rodenburg RJ, Wevers RA, Pacak K, Eisenhofer G, Qin N, Kusters B, Goudswaard AG, Lenders JW, Hermus AR, Mensenkamp AR, Kunst HP, Sweep FC, Timmers HJ

     

• SDH mutations establish a hypermethylator phenotype in paraganglioma.

  Cancer cell. 2013 Jun 10;23(6):739-52

  Authors: Letouzé E, Martinelli C, Loriot C, Burnichon N, Abermil N, Ottolenghi C, Janin M, Menara M, Nguyen AT, Benit P, Buffet A, Marcaillou C, Bertherat J, Amar L, Rustin P, De Reyniès A, Gimenez-Roqueplo AP, Favier J

  

• Paragangliomas: update on differential diagnostic considerations, composite tumors, and recent genetic developments.

  Seminars in diagnostic pathology. 2013 Aug;30(3):207-23

  Authors: Papathomas TG, de Krijger RR, Tischler AS

  

• Analysis of plasma 3-methoxytyramine, normetanephrine and metanephrine by ultraperformance liquid chromatography-tandem mass spectrometry: utility for diagnosis of dopamine-producing metastatic phaeochromocytoma.

  Annals of clinical biochemistry. 2013 Mar;50(Pt 2):147-55

  Authors: Peitzsch M, Prejbisz A, Kroiß M, Beuschlein F, Arlt W, Januszewicz A, Siegert G, Eisenhofer G

  

• [¹²³I]Iodometomidate imaging in adrenocortical carcinoma.

  The Journal of clinical endocrinology and metabolism. 2013 Jul;98(7):2755-64

  Authors: Kreissl MC, Schirbel A, Fassnacht M, Haenscheid H, Verburg FA, Bock S, Saeger W, Knoedler P, Reiners C, Buck AK, Allolio B, Hahner S

  

• Diagnostic and prognostic role of steroidogenic factor 1 in adrenocortical carcinoma: a validation study focusing on clinical and pathologic correlates.

  Human pathology. 2013 May;44(5):822-8

  Authors: Duregon E, Volante M, Giorcelli J, Terzolo M, Lalli E, Papotti M

  

• Impact of neonatal screening and surveillance for the TP53 R337H mutation on early detection of childhood adrenocortical tumors.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2013 Jul 10;31(20):2619-26

  Authors: Custódio G, Parise GA, Kiesel Filho N, Komechen H, Sabbaga CC, Rosati R, Grisa L, Parise IZ, Pianovski MA, Fiori CM, Ledesma JA, Barbosa JR, Figueiredo FR, Sade ER, Ibañez H, Arram SB, Stinghen ST, Mengarelli LR, Figueiredo MM, Carvalho DC, Avilla SG, Woiski TD, Poncio LC, Lima GF, Pontarolo R, Lalli E, Zhou Y, Zambetti GP, Ribeiro RC, Figueiredo BC

     

• Integrative analysis of SF-1 transcription factor dosage impact on genome-wide binding and gene expression regulation.

  Nucleic acids research. 2013 Oct;41(19):8896-907

  Authors: Doghman M, Figueiredo BC, Volante M, Papotti M, Lalli E

     

• Beyond steroidogenesis: novel target genes for SF-1 discovered by genomics.

  Molecular and cellular endocrinology. 2013 May 22;371(1-2):154-9

  Authors: Lalli E, Doghman M, Latre de Late P, El Wakil A, Mus-Veteau I

  

2012

• Combination of sorafenib and everolimus impacts therapeutically on adrenocortical tumor models.

  Endocrine-related cancer. 2012 Aug;19(4):527-39

  Authors: Mariniello B, Rosato A, Zuccolotto G, Rubin B, Cicala MV, Finco I, Iacobone M, Frigo AC, Fassina A, Pezzani R, Mantero F

  

• Staging and functional characterization of pheochromocytoma and paraganglioma by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography.

  Journal of the National Cancer Institute. 2012 May 2;104(9):700-8

  Authors: Timmers HJ, Chen CC, Carrasquillo JA, Whatley M, Ling A, Eisenhofer G, King KS, Rao JU, Wesley RA, Adams KT, Pacak K

     

• MAX mutations cause hereditary and sporadic pheochromocytoma and paraganglioma.

  Clinical cancer research : an official journal of the American Association for Cancer Research. 2012 May 15;18(10):2828-37

  Authors: Burnichon N, Cascón A, Schiavi F, Morales NP, Comino-Méndez I, Abermil N, Inglada-Pérez L, de Cubas AA, Amar L, Barontini M, de Quirós SB, Bertherat J, Bignon YJ, Blok MJ, Bobisse S, Borrego S, Castellano M, Chanson P, Chiara MD, Corssmit EP, Giacchè M, de Krijger RR, Ercolino T, Girerd X, Gómez-García EB, Gómez-Graña A, Guilhem I, Hes FJ, Honrado E, Korpershoek E, Lenders JW, Letón R, Mensenkamp AR, Merlo A, Mori L, Murat A, Pierre P, Plouin PF, Prodanov T, Quesada-Charneco M, Qin N, Rapizzi E, Raymond V, Reisch N, Roncador G, Ruiz-Ferrer M, Schillo F, Stegmann AP, Suarez C, Taschin E, Timmers HJ, Tops CM, Urioste M, Beuschlein F, Pacak K, Mannelli M, Dahia PL, Opocher G, Eisenhofer G, Gimenez-Roqueplo AP, Robledo M

  

• KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism.

  Hypertension (Dallas, Tex. : 1979). 2012 Feb;59(2):235-40

  Authors: Mulatero P, Tauber P, Zennaro MC, Monticone S, Lang K, Beuschlein F, Fischer E, Tizzani D, Pallauf A, Viola A, Amar L, Williams TA, Strom TM, Graf E, Bandulik S, Penton D, Plouin PF, Warth R, Allolio B, Jeunemaitre X, Veglio F, Reincke M

  

• Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism.

  Hypertension (Dallas, Tex. : 1979). 2012 Mar;59(3):592-8

  Authors: Boulkroun S, Beuschlein F, Rossi GP, Golib-Dzib JF, Fischer E, Amar L, Mulatero P, Samson-Couterie B, Hahner S, Quinkler M, Fallo F, Letizia C, Allolio B, Ceolotto G, Cicala MV, Lang K, Lefebvre H, Lenzini L, Maniero C, Monticone S, Perrocheau M, Pilon C, Plouin PF, Rayes N, Seccia TM, Veglio F, Williams TA, Zinnamosca L, Mantero F, Benecke A, Jeunemaitre X, Reincke M, Zennaro MC

  

• Xenograft models for preclinical drug testing: implications for adrenocortical cancer.

  Molecular and cellular endocrinology. 2012 Mar 31;351(1):71-7

  Authors: Luconi M, Mannelli M

  

• Animal models of adrenocortical tumorigenesis.

  Molecular and cellular endocrinology. 2012 Mar 31;351(1):78-86

  Authors: Beuschlein F, Galac S, Wilson DB

     

• SNP array profiling of childhood adrenocortical tumors reveals distinct pathways of tumorigenesis and highlights candidate driver genes.

  The Journal of clinical endocrinology and metabolism. 2012 Jul;97(7):E1284-93

  Authors: Letouzé E, Rosati R, Komechen H, Doghman M, Marisa L, Flück C, de Krijger RR, van Noesel MM, Mas JC, Pianovski MA, Zambetti GP, Figueiredo BC, Lalli E

  

• Gene expression profiling in adrenocortical neoplasia.

  Molecular and cellular endocrinology. 2012 Mar 31;351(1):111-7

  Authors: Assie G, Giordano TJ, Bertherat J

  

• Clinical and pathophysiological implications of chromosomal alterations in adrenocortical tumors: an integrated genomic approach.

  The Journal of clinical endocrinology and metabolism. 2012 Feb;97(2):E301-11

  Authors: Barreau O, de Reynies A, Wilmot-Roussel H, Guillaud-Bataille M, Auzan C, René-Corail F, Tissier F, Dousset B, Bertagna X, Bertherat J, Clauser E, Assié G

  

• Adrenocortical cancer in Carney complex: a paradigm of endocrine tumor progression or an association of genetic predisposing factors?

  The Journal of clinical endocrinology and metabolism. 2012 Feb;97(2):387-90

  Authors: Bertherat J

  

• The ENSAT registry: a digital repository supporting adrenal cancer research.

  Studies in health technology and informatics. 2012;178:207-12

  Authors: Stell A, Sinnott R

  

• Efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 in a preclinical model of adrenocortical carcinoma.

  Molecular and cellular endocrinology. 2012 Nov 25;364(1-2):101-4

  Authors: Doghman M, Lalli E

  

• An update on the genetics of paraganglioma, pheochromocytoma, and associated hereditary syndromes.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2012 May;44(5):328-33

  Authors: Gimenez-Roqueplo AP, Dahia PL, Robledo M

  

• Adrenocortical neoplasia: evolving concepts in tumorigenesis with an emphasis on adrenal cortical carcinoma variants.

  Virchows Archiv : an international journal of pathology. 2012 Jan;460(1):9-18

  Authors: de Krijger RR, Papathomas TG

     

• Plasma methoxytyramine: a novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status.

  European journal of cancer (Oxford, England : 1990). 2012 Jul;48(11):1739-49

  Authors: Eisenhofer G, Lenders JW, Siegert G, Bornstein SR, Friberg P, Milosevic D, Mannelli M, Linehan WM, Adams K, Timmers HJ, Pacak K

     

2011